Serum homocysteine levels and paraoxonase 1 activity in preschool aged children in Greece

dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Κριεμπάρδης, Αναστάσιος Γ.	el
dc.contributor.author	Σαμαρά, Ιωάννα	el
dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Παπαχριστοδούλου, Μαρία	el
dc.date.accessioned	2015-05-08T19:05:23Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/9987
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/16681435?dopt=AbstractPlus	en
dc.subject	ηλικία
dc.subject	καρδιαγγειακή πάθηση
dc.subject	ομοκυστεΐνης
dc.subject	παραοξονάση
dc.subject	φύλο
dc.subject	age
dc.subject	cardiovascular disease
dc.subject	Homocysteine
dc.subject	Paraoxonase
dc.subject	sex
dc.title	Serum homocysteine levels and paraoxonase 1 activity in preschool aged children in Greece	en
heal.type	journalArticle
heal.classification	Χημεία, Κλινική
heal.classification	Παιδιά
heal.classification	Clinical chemistry
heal.classification	Children
heal.classificationURI	N/A-Χημεία, Κλινική
heal.classificationURI	N/A-Παιδιά
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85023014
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85023418
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh96011736
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2002008729
heal.contributorName	Φύτου-Παλληκάρη, Αθηνά	el
heal.identifier.secondary	DOI: 10.1515/CCLM.2006.110
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2006-05
heal.bibliographicCitation	Karikas, G.A., Kriebardis, A., Samara, I., Schulpis, K., Papachristodoulou, M. et al. (2006) Serum homocysteine levels and paraoxonase 1 activity in preschool aged children in Greece. Clinical Chemistry and Laboratory Medicine. [Online] 44 (5). pp.623-627. Available from: http://www.ncbi.nlm.nih.gov [Accessed 08/05/2015]	en
heal.abstract	Background: Over the past decade, it has been well established that elevated total serum homocysteine (tHcy) in adults is associated with increased risk of cardiovascular and thromboembolic diseases. Since risk factors for such diseases are established at a young age, the aim of the present study was to measure serum tHcy levels in 134 (71 boys, 63 girls) randomly selected healthy preschool children aged 4–6 years (mean 5.1), and to investigate possible correlation with paraoxonase 1 (PON1) activity, an antioxidant enzyme that contributes to the antiatherogenic properties of high-density lipoprotein (HDL). Methods: tHcy was determined using an IMX tHcy assay (FPIA). PON1 was measured by a spectrophotometric method at 412 nm. Results: Mean serum tHcy was 7.71±2.35 μmol/L. A relatively significant percentage (15.6%) of boys and girls had elevated serum tHcy levels (>10 μmol/L). tHcy levels were slightly higher in girls compared to boys (8.20±2.80 vs. 7.29±1.79 μmol/L, respectively; p<0.11). There was no significant interaction between age and tHcy levels. Mean PON1 activity was 124.86±66.62 U/L. No statistical difference in enzyme activity was observed between boys and girls (126.81±69.99 vs. 121.74±64.78 U/L) was observed. On the contrary, a weak negative relationship between tHcy concentration and PON1 activity was detected, with Pearson's correlation coefficient of r=−0.27. Conclusions: The significant percentage of elevated tHcy levels observed in healthy preschool cases and the negative tHcy correlation with PON1 activity are reported for the first time. Since children with a family history of cardiovascular disease have higher levels of serum Hcy, tHcy screening in children, even of this age, in relation to other parameters, such the protective PON1, might prove a useful prevention procedure for the genetic risk of premature atherosclerosis.	en
heal.journalName	Clinical Chemistry and Laboratory Medicine (CCLM)	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false