Valproic acid monotherapy induces DNA oxidative damage

dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Λαζαροπούλου, Χριστίνα	el
dc.contributor.author	Ρεγκούτας, Σπύρος	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Μαργέλη, Αλεξάνδρα	el
dc.date.accessioned	2015-05-08T19:33:40Z
dc.date.available	2015-05-08T19:33:40Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/9992
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com/science/article/pii/S0300483X05005019	en
dc.subject	βαλπροϊκό οξύ
dc.subject	ελεύθερες ρίζες
dc.subject	βιοδείκτης
dc.subject	Οξειδωτικές βλάβες του DNA
dc.subject	Valproic acid
dc.subject	free radicals
dc.subject	biomarkers
dc.subject	DNA oxidative damage
dc.title	Valproic acid monotherapy induces DNA oxidative damage	en
heal.type	journalArticle
heal.classification	Χημεία
heal.classification	Τοξικολογία
heal.classification	Chemistry
heal.classification	Toxicology
heal.classificationURI	N/A-Χημεία
heal.classificationURI	N/A-Τοξικολογία
heal.classificationURI	http://skos.um.es/unescothes/C00568
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh2002007680
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85141922
heal.keywordURI	http://lod.nal.usda.gov/41501
heal.keywordURI	http://lod.nal.usda.gov/17262
heal.contributorName	Τσακίρης, Στυλιανός	el
heal.contributorName	Παπασωτηρίου, Ιωάννης	el
heal.identifier.secondary	DOI: 10.1016/j.tox.2005.10.004
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2006-01
heal.bibliographicCitation	Schulpis, K.H., Lazaropoulou, C., Regoutas, S., Karikas, G.A., Margeli, A. et al. (2006) Valproic acid monotherapy induces DNA oxidative damage. Toxicology. [Online] 217 (2-3). pp.228-232. Available from: http://www.sciencedirect.com [Accessed 08/05/2015]	en
heal.abstract	Valproic acid (VPA) and 8-hydroxy-2-deoxyguanosine (8-OHdG) are implicated with the free radicals production. We aimed to evaluate total oxidant status (TOS) and 8-OHdG in children on VPA monotherapy. Fifty patients with seizures, mean age 8.5 ± 3.6 years, were divided into group A (N = 26) and group B (N = 24) with VPA serum levels 81.0 ± 8.0 and 114 ± 9.7 μg/mL, respectively. Thirty healthy children were the controls. Liver function tests and lipids were determined with routine methods, TOS and 8-OHdG with commercial kits, after 60 days on VPA therapy. Liver function parameters, lipids, TOS (647 ± 43 μmol/L) and 8-OHdG (0.49 ± 0.08 ng/mL) were significantly higher in group B than those in group A (580 ± 40 μmol/L, 0.37 ± 0.04 ng/mL, p < 0.001) and controls (124 ± 30 μmol/L, 0.11 ± 0.04 ng/mL, p < 0.001, respectively). Significant correlation coefficients were found between 8-OHdG versus TOS (r = 0.67, p < 0.001) and 8-OHdG versus VPA (r = 0.60, p < 0.001) levels. It is suggested that VPA impairs the liver function resulting in free radicals production. The latter seems to produce DNA oxidative damage in liver cells, not excluding neuronal cells, as evidenced by the measured remarkably increased 8-OHdG serum levels. 8-OHdG evaluation may be a useful biomarker to follow up the increased risk of degeneration process in VPA patients.	en
heal.publisher	Elsevier	en
heal.journalName	Toxicology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true