National and institutional policies in Greece intensively foment the reformation of Higher Education (HE) in order to build upon the potential of new Information and Communication Technologies (ICT). The integration of e-learning approaches currently constitutes a high priority issue for tertiary educational institutions. It is important however to take into account the different learner profiles encountered in the higher educational context. Our work emphasizes on issues concerning the design of accessible, adaptive, usable, web-based lessons for learners with the cognitive disability of dyslexia.