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dc.contributor.author Τσουκάτος, Δημόκριτος Χ. el
dc.contributor.author Brochériou, Isabelle fr
dc.contributor.author Μούσσης, Βασίλειος el
dc.contributor.author Πανοπούλου, Χριστίνα Π. el
dc.contributor.author Χριστοφίδου, Έλενα Δ. el
dc.date.accessioned 2015-05-28T05:45:29Z
dc.date.available 2015-05-28T05:45:29Z
dc.date.issued 2015-05-28
dc.identifier.uri http://hdl.handle.net/11400/11316
dc.rights Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.source http://www.jlr.org/content/49/10/2240 el
dc.subject atherogenesis
dc.subject Atherosclerosis
dc.subject Lipoproteins
dc.subject Macrophages
dc.subject Αθηρογένεση
dc.subject Αθηροσκλήρωση
dc.subject Λιποπρωτεΐνες
dc.subject Μακροφάγα
dc.subject Oxidized LDL
dc.subject Οξειδωμένη LDL
dc.subject Smooth muscle cells
dc.subject Κύτταρα λείου μυός
dc.title Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery en
heal.type journalArticle
heal.classification Medicine
heal.classification Biochemistry
heal.classification Ιατρική
heal.classification Βιοχημεία
heal.classificationURI http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI http://skos.um.es/unescothes/C00386
heal.classificationURI **N/A**-Ιατρική
heal.classificationURI **N/A**-Βιοχημεία
heal.keywordURI http://lod.nal.usda.gov/13589
heal.keywordURI http://skos.um.es/unesco6/320702
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85077309
heal.keywordURI http://id.loc.gov/authorities/subjects/sh85079451
heal.contributorName Κουσίσης, Σταμάτης el
heal.contributorName Σισμανίδης, Σωκράτης el
heal.contributorName Ninio, Ewa en
heal.contributorName Συμινελάκης, Σταύρος Ν. el
heal.identifier.secondary ISSN: 00222275
heal.identifier.secondary DOI: 10.1194/jlr.M800188-JLR200
heal.language en
heal.access campus
heal.recordProvider Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Τεχνολογίας Τροφίμων & Διατροφής. Τμήμα Τεχνολογίας Τροφίμων el
heal.publicationDate 2008-10
heal.bibliographicCitation Tsoukatos, D. C., Brochériou, I., Moussis, V., PanopoUlou C. P., Christofidou, E. D., et.al. (2008). Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery. "Journal of Lipid Research", 49(10), October 2008. pp 2240-2249. Available from: http://www.jlr.org/content/49/10/2240. [Accessed 27/06/2008] en
heal.abstract Platelet-activating factor (PAF), the potent phospholipid mediator of inflammation, is involved in atherosclerosis. Platelet-activating factor-acetylhydrolase (PAF-AH), the enzyme that inactivates PAF bioactivity, possesses both acetylhydrolase and transacetylase activities. In the present study, we measured acetylhydrolase and transacetylase activities in human atherogenic aorta and nonatherogenic mammary arteries. Immunohistochemistry analysis showed PAF-AH expression in the intima and the media of the aorta and in the media of mammary arteries. Acetylhydrolase and transacetylase activities were (mean ± SE, n = 38): acetylhydrolase of aorta, 2.8 ± 0.5 pmol/ min/mg of tissue; transacetylase of aorta, 3.3 ± 0.7 pmol/min/mg of tissue; acetylhydrolase of mammary artery, 1.4 ± 0.3 pmol/min/ mg of tissue (P< 0.004 as compared with acetylhydrolase of aorta); transacetylase of mammary artery, 0.8 ± 0.2 pmol/min/mg of tissue (P < 0.03 as compared with acetylhydrolase of mammary artery). Lyso-PAF accumulation and an increase in PAF bioactivity were observed in the aorta of some patients. Reverse-phase HPLC and electrospray ionization mass spectrometry analysis revealed that 1-O-hexadecyl-2 acetyl-sn glycero-3-phosphocholine accounted for 60% of the PAF bioactivity and 1-O-hexadecyl-2-butanoyl-sn-glycerol-3-phosphocholine for 40% of the PAF bioactivity. The nonatherogenic properties of mammary arteries may in part be due to low PAF formation regulated by PAF-AH activity. In atherogenic aortas, an imbalance between PAF-AH and transacetylase activity, as well as lyso-PAF accumulation, may lead to unregulated PAF formation and to progression of atherosclerosis en
heal.publisher American Society for Biochemistry and Molecular Biology en
heal.journalName Journal of Lipid Research en
heal.journalType peer-reviewed
heal.fullTextAvailability true


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Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες Except where otherwise noted, this item's license is described as Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες