A holistic approach of erythropoiesis and iron in anemia

dc.contributor.author	Κυριαζή, Βασιλική	el
dc.date.accessioned	2014-07-15T09:54:57Z
dc.date.available	2014-07-15T09:54:57Z
dc.date.issued	2014-07-15
dc.identifier.uri	http://hdl.handle.net/11400/1303
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	www.hsj.gr	en
dc.subject	Erythropoiesis
dc.subject	Iron--Metabolism
dc.subject	Chronic disease
dc.subject	Χρόνια ασθένεια
dc.subject	Ανεμία
dc.subject	Hepcidin
dc.subject	Anemia
dc.title	A holistic approach of erythropoiesis and iron in anemia	en
heal.type	journalArticle
heal.generalDescription	Review	en
heal.classification	Medicine
heal.classification	Ιατρική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	N/A-Ιατρική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85044755
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85068202
heal.keywordURI	http://zbw.eu/stw/descriptor/28859-2
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2011-09
heal.bibliographicCitation	Kyriazi, V.. (2011). A holistic approach of erythropoiesis and iron in anemia. Health Science Journal". 5 (3), 176-81.	en
heal.abstract	Background: Iron (Fe) metabolism is dependent on heme biosynthesis in bone marrow erythroblasts and is strictly controlled. Failure of this process induces to absolute or functional iron deficiency anemia (IDA), which is common in general medical practice. Aim: This study summarizes the Fe role in normal and disturbed erythopoietic process and focuses on current biochemical indicators and available therapeutic options for Fe imbalance. Methods: A systematic review in PubMed, MedLine and MDConsult database was conducted. The research limits included English abstracts and full texts, referring to erythropoiesis, anemia and Fe during the last decade. Results: Erythrocyte delivers oxygen to the tissues, so the primary consequence of anemia is tissue hypoxia. Oxygen-sensing cells in kidney respond to hypoxia by increasing erythropoietin (EPO), the basic regulatory hormone of erythropoiesis. Fe is an essential micronutrient for adequate erythropoietic function. Anemia of chronic disease (ACD) and IDA are characterized by disturbances in Fe homeostasis. In addition, inflammatory disorders and renal insufficiency are complicated by severe depression of EPO levels. Red cell indices (hemoglobin, mean cell hemoglobin) and biochemical markers (ferritin, transferrin saturation and receptors) reflect hemoglobin biosynthesis and iron pathways. The therapy of underlying disease is essential in IDA and ACD, whereas adjuvant procedures are red blood cells transfusion, erythropoietic agents and Fe supplementation. Conclusion: The approach of Fe-deficient patient is complex and based on wide range of clinical and laboratory findings. The precise evaluation of them is critical for diagnosis and management modalities.	en
heal.publisher	Μαρβάκη, Χριστίνα	el
heal.journalName	Health Science Journal	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true
heal.dateCreated	2011-07