Background: Studies and surveys show that sexual abuse and exploitation of children is becoming bigger, and now there is not a problem involving only developing countries in Asia and Africa. The phenomenon of sexual abuse and exploitation of children is a very old global phenomenon that is perpetuated. Nurses, in cooperation with a multidisciplinary team, can provide important services to children who are victims of sexual abuse. Aim: The presentation based on international literature review, of the role of nurses in child sexual abuse in USA. Material and Methods: Method was used is to search electronic databases (MEDLINE, CINAHL) for a review of international literature until 2009 and became selection of books, articles and studies from libraries. Results: Nurses meet abused children and their families in emergency departments, urgent care centers, clinics and offices. Nurses can play a vital role in helping these children and their families by activating a team of people who will respond to the child’s disclosure. The most important role for a nurse is to ensure the health and safety of the child. At times, nurse with proper training can also collect and preserve forensic evidence. Conclusion: Nurse can play a very important role in the health and welfare of children who have experienced sexual abuse. All cases of suspected child abuse should be reported to the appropriate authorities.