Endogenous estradiol, estrogen and progesterone receptors increase benign and breast cancer risk among non-familial postmenopausal females

dc.contributor.author	Atoum, Manar	en
dc.contributor.author	Al-Hourani, Huda	en
dc.contributor.author	Nimer, Nisreen	en
dc.contributor.author	Almuhrib, Tgreed	en
dc.contributor.author	Raheem, Sabah	en
dc.date.accessioned	2014-07-20T08:21:52Z
dc.date.available	2014-07-20T08:21:52Z
dc.date.issued	2014-07-20
dc.identifier.uri	http://hdl.handle.net/11400/1445
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	www.hsj.gr	en
dc.subject	Estradiol
dc.subject	Prolactin
dc.subject	Selective estrogen receptor modulators
dc.subject	Οιστρογόνα
dc.subject	Familial
dc.title	Endogenous estradiol, estrogen and progesterone receptors increase benign and breast cancer risk among non-familial postmenopausal females	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Gynecology
heal.classification	Oncology
heal.classification	Midwifery
heal.classification	Ιατρική
heal.classification	Γυναικολογία
heal.classification	Ογκολογία
heal.classification	Μαιευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85058092
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh96006072
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85094724
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Γυναικολογία
heal.classificationURI	N/A-Μαιευτική
heal.classificationURI	N/A-Ογκολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85045006
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85107391
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh98005058
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2012-12
heal.bibliographicCitation	Atoum, M., Al-Hourani, H., Nimer, N. & Almuhrib, T. (December 2012) Endogenous estradiol, estrogen and progesterone receptors increase benign and breast cancer risk among non-familial postmenopausal females. “Health Science Journal”. 6 (4). p. 693-702.	el
heal.abstract	Background: Hormones and genetics play a critical role in breast cancer development, determining the association between plasma hormones and breast cancer risk among familial and non-familial females may provide insight into the etiology of breast cancer. Material and Methods: 140 postmenopausal females during the period between June 2007 and May 2011 were enrolled in this study, 83 were breast cancer patients and 57 were benign patients. Plasma estradiol, progesterone and prolactin levels were estimated among familial and non-familial breast cancer females. Estrogen and progesterone receptor status was determined for all breast cancer and benign females. Results: 20% of non-familial breast cancer and 16% of benign females have abnormal prolactin. 4% of non-familial breast cancer and 12% of benign females have abnormal progesterone. On the other hand, 57% of non-familial breast cancer females and 44% of non-familial benign females have abnormal serum estradiol. Plasma levels of estradiol were significantly associated with benign and breast cancer risk among both familial and non-familial females. While plasma levels of prolactin were significantly associated with breast cancer risk among non-familial females. Positive estrogen and progesterone receptors associated with increased benign or breast cancer risk among non-familial with high estradiol levels. Conclusion: Abnormal plasma estradiol and positive estrogen and progesterone receptors associated with increased risk among postmenopausal both among non familial benign and breast cancer females. These findings suggest that estradiol, prolactin and estrogen and progesterone receptors evaluation might be useful to better identify females with non-familial hormone-dependent disease that should be considered in breast cancer pathogenesis as well as in the treatments.	en
heal.publisher	Μαρβάκη, Χριστίνα	el
heal.journalName	Health Science Journal	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true
heal.dateCreated	2012-10