Blood transfusion improves tissue oxygenation in beta-thalassemia major patients

dc.contributor.author	Βασιλειάδης, Ιωάννης	el
dc.contributor.author	Μπάσιος, Νεόφυτος	el
dc.contributor.author	Γεροβασίλη, Βασιλική	el
dc.contributor.author	Δημόπουλος, Σταύρος	el
dc.contributor.author	Λαδής, Βασίλειος	el
dc.date.accessioned	2014-07-20T15:26:34Z
dc.date.available	2014-07-20T15:26:34Z
dc.date.issued	2014-07-20
dc.identifier.uri	http://hdl.handle.net/11400/1473
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	www.hsj.gr	en
dc.subject	Near infrared spectroscopy
dc.subject	Blood--transfusion
dc.subject	Thalassemia
dc.subject	Μεσογειακή αναιμία
dc.subject	Οξυγόνωση ιστού
dc.subject	NIRS
dc.subject	Μετάγγιση αιματος
dc.subject	Tissue oxygenation
dc.subject	Beta-thalassemia
dc.subject	β-θαλασσαιμία
dc.title	Blood transfusion improves tissue oxygenation in beta-thalassemia major patients	en
heal.type	journalArticle
heal.generalDescription	Research article	en
heal.classification	Medicine
heal.classification	Ιατρική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	N/A-Ιατρική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh88002315
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85134466
heal.contributorName	Κομπότη, Μαρία	el
heal.contributorName	Νανάς, Σεραφείμ Ν.	el
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2013-12
heal.bibliographicCitation	Vasileiadis, I., Basios, N., Gerovasili, V. & Dimopoulos, S. (December 2013). Blood transfusion improves tissue oxygenation in beta-thalassemia major patients. “Health Science Journal”. 7(4):448-455.	en
heal.abstract	Background: Red blood cell (RBC) transfusion is the treatment basis in beta-thalassemia major. Aim: With the present study we aimed to investigate the effect of RBC transfusions on tissue oxygenation, in beta-thalassemics. Microcirculatory indices obtained by Near Infrared Spectroscopy (NIRS) were utilized. Methods: The relative oxyhemoglobin concentration in tissues (StO2), as assessed by NIRS, was measured before and 30 min after a regular transfusion, in 17 consecutive beta-thalassemia major patients. The NIRS probe was placed on the thenar eminence. The oxygen consumption rate (%/min) during a 3 min vascular occlusion and the reperfusion rate after occlusion release were also estimated. Results: The patients received 7.85±1.98 ml/kg packed leukocyte-depleted RBC. StO2 increased significantly after RBC transfusion compared to baseline (90% vs. 88% respectively, p=0.002). Delta StO2 (StO2 change after RBC transfusion) showed a significant negative correlation with baseline StO2. The O2 consumption rate after occlusion showed no significant change after RBC transfusion, while the reperfusion rate displayed an increasing trend of borderline significance (p=0.076). Conclusion: The present study indicates that regular RBC transfusions improve microcirculation in beta-thalassemia major patients.	en
heal.publisher	Μαρβάκη, Χριστίνα	el
heal.journalName	Health Science Journal	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true
heal.dateCreated	2013-10