The objective of this study was to formulate and evaluate of sustained release matrix tablet of Tizanidine Hydrochloride by direct compression technique. Tizanidine hydrochloride tablets were prepared by melt direct compression technique using xanthum gum, guar gum, Glyceryl behenate, Glyceryl monostearate and Stearic acid in different proportion. Formulated sustain release tablets were evaluated for appearance, dimensions (diameter and thickness), weight variation, hardness, friability, drug content and in-vitro release of Tizanidine hydrochloride. Optimized batch was compared with marketed preparation. The result indicated the formulation containing Glyceryl behenate (30%) showed the release profile similar to marketed preparation with satisfactory physical properties of tablet. It is feasible to formulate sustained release tablet of Tizanidine hydrochloride with acceptable physical properties which could be amenable to replication on an industrial scale.