Formulation and evaluation of sustained release matrix tablet of tizanidine hydrochloride by direct compression technique

dc.contributor.author	Patel, Rakesh P.	en
dc.contributor.author	Patel, Mehul H.	en
dc.contributor.author	Prajapati, Bhupendra G.	en
dc.contributor.author	Baria, Ashok H.	en
dc.date.accessioned	2015-02-01T21:11:31Z
dc.date.available	2015-02-01T21:11:31Z
dc.date.issued	2015-02-01
dc.identifier.uri	http://hdl.handle.net/11400/5392
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Glyceryl
dc.subject	Γλυκερύλιο
dc.subject	Tizanidine hydrochloride
dc.subject	Sustained release matrix tablet
dc.subject	Υδροχλωρική τιζανιδίνη
dc.subject	Δισκίο παρατεταμένης αποδέσμευσης μήτρας
dc.title	Formulation and evaluation of sustained release matrix tablet of tizanidine hydrochloride by direct compression technique	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Pharmacy
heal.classification	Ιατρική
heal.classification	Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	N/A-Pharmacy
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακευτική
heal.language	en
heal.access	free
heal.publicationDate	2011
heal.bibliographicCitation	Patel, R.P., Patel, M.H., Prajapati, B.G. and Baria, A.H. (2011). Formulation and evaluation of sustained release matrix tablet of tizanidine hydrochloride by direct compression technique. "e-Journal of Science & Technology". [Online] 6(1): 69-81. Available from: http://e-jst.teiath.gr/	en
heal.abstract	The objective of this study was to formulate and evaluate of sustained release matrix tablet of Tizanidine Hydrochloride by direct compression technique. Tizanidine hydrochloride tablets were prepared by melt direct compression technique using xanthum gum, guar gum, Glyceryl behenate, Glyceryl monostearate and Stearic acid in different proportion. Formulated sustain release tablets were evaluated for appearance, dimensions (diameter and thickness), weight variation, hardness, friability, drug content and in-vitro release of Tizanidine hydrochloride. Optimized batch was compared with marketed preparation. The result indicated the formulation containing Glyceryl behenate (30%) showed the release profile similar to marketed preparation with satisfactory physical properties of tablet. It is feasible to formulate sustained release tablet of Tizanidine hydrochloride with acceptable physical properties which could be amenable to replication on an industrial scale.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true