Formulation and in-vitro evaluation of microbially triggered colon specific drug delivery using sesbania gum

dc.contributor.author	Patel, Girish N.	en
dc.contributor.author	Patel, R. B.	en
dc.contributor.author	Patel, H. R.	en
dc.date.accessioned	2015-02-02T06:47:08Z
dc.date.available	2015-02-02T06:47:08Z
dc.date.issued	2015-02-02
dc.identifier.uri	http://hdl.handle.net/11400/5410
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Metronidazole
dc.subject	Μετρονιδαζόλη
dc.subject	Sesbania gum
dc.subject	Microbially triggered
dc.subject	Compression coated
dc.title	Formulation and in-vitro evaluation of microbially triggered colon specific drug delivery using sesbania gum	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Medical physics
heal.classification	Ιατρική
heal.classification	Ιατρική φυσική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85083001
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ιατρική φυσική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85084449
heal.language	en
heal.access	free
heal.publicationDate	2011
heal.bibliographicCitation	Patel, G.N., Patel, R.B. and Patel, H.R. (2011). Formulation and in-vitro evaluation of microbially triggered colon specific drug delivery using sesbania gum. "e-Journal of Science & Technology". [Online] 6(2): 33-45. Available from: http://e-jst.teiath.gr/	en
heal.abstract	The aim of the present study is to develop colon targeted drug delivery systems for metronidazole using sesbania gum as a carrier. Matrix, enteric coated and compression coated tablets of metronidazole containing various proportions of sesbania gum were prepared. All the formulations were evaluated for the hardness, drug content uniformity, and were subjected to in vitro drug release studies. Matrix tablets and enteric coated tablets of metronidazole released 41–71% and 25–28% of the metronidazole, respectively, in the physiological environment of stomach and small intestine depending on the proportion of sesbania gum used in the formulation. Both the formulations failed to control the drug release within 5 hr. The compression coated formulations (CS2) released less than 5% of metronidazole in the physiological environment of stomach and small intestine. When the dissolution study was continued in simulated colonic fluids, the compression coated tablet with 150 mg of sesbania gum coat released another 76% of metronidazole after degradation by colonic bacteria at the end of 12 hr.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true