Associations between pon1 and cyp1a1 genetic polymorphisms and clinical findings of a Greek population exposed to pesticides

dc.contributor.author	Αλεγάκης, Αθανάσιος	el
dc.contributor.author	Ζαφειρόπουλος, Αλξέξανδρος	el
dc.contributor.author	Τζανακάκης, Γεώργιος	el
dc.contributor.author	Κουτής, Χαρίλαος	el
dc.contributor.author	Τσατσάκης, Αριστείδης Μ.	el
dc.date.accessioned	2015-04-22T14:54:12Z
dc.date.issued	2015-04-22
dc.identifier.uri	http://hdl.handle.net/11400/8688
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	www.sciencedirect.com	en
dc.subject	Greece
dc.subject	Ελλάδα
dc.subject	αγροτικές περιοχές
dc.subject	rural areas
dc.title	Associations between pon1 and cyp1a1 genetic polymorphisms and clinical findings of a Greek population exposed to pesticides	en
heal.type	journalArticle
heal.classification	Public health
heal.classification	Medicine
heal.classification	Δημόσια υγεία
heal.classification	Ιατρική
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Δημόσια υγεία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://lod.nal.usda.gov/28292
heal.keywordURI	http://zbw.eu/stw/descriptor/17184-0
heal.identifier.secondary	DOI: 10.1016/j.toxlet.2009.06.557
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.publicationDate	2009
heal.bibliographicCitation	Alegakis, A., Zafiropoulos, A., Tzanakakis, G., Liesivuori, J., Koutis, Ch., et. al. (2009) Associations between PON1 and CYP1A1 genetic polymorphisms and clinical findings of a Greek population exposed to pesticides. "Toxicology Letters". [Online] 189: pp.214-215. Available from: http://www.sciencedirect.com [Accessed 22/04/2015]	el
heal.abstract	Background-Introduction: Little is known about the role of CYP1A1 and PON1 allelic variants as risk factors for human diseases although they have been extensively studied for toxic response. Purpose: The examination of possible associations of CYP1A1 and PON1 – which are suspect factors for toxic response – with studied diseases and symptoms. Study methods: This is a cross-sectional study. Participants were randomly selected from the rural region of Amaliada, Peloponnesus, Greece. A total of 181 individuals have been participated in hair samples collection, blood samples and interviewed for medical history. Statistics include Pearson's chi-square test and Fisher's exact test as measures of association. Results: Analysis of the genetic data revealed that the allele frequencies of PON1 R, M and CYP1A1*2A alleles were 0.226, 0.383 and 0.120, respectively. Crude analysis of the genetic data revealed an association of angina pectoris with PON1 Q192R (p = 0.041). Hepatitis is significantly associated with PON1 L55 M (p < 0.002), with CYP1A1 MSP1 (p = 0.028). A tendency for association is observed between ulcer and CYP1A1 MSP1 (p = 0.069), hemorrhoids and CYP1A1 MSP1 (p = 0.078). Hypertension is significantly associated with PON1 L55 M (p = 0.048) and PON1 Q192R (p = 0.038). Corresponding results showed between prostate and urination disorders with PON1 Q192R (p = 0.004), PON1 L55 M (p = 0.019). Conclusion: Our results demonstrated an association between the CYP1A1/PON1 polymorphisms and several medical examination findings, thus indicating the possible involvement of the human detoxification system to health effects in a rural population exposed professionally to pesticides.	el
heal.journalName	Toxicology Letters	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true