This article aims to examine the effects of High performance Working Systems in organizations after a major change, like a merger or an acquisition, in the organization of a company that use Informative technology in manufacturing sector, in Greece. For this purpose this article is based on a theoretical research in the recent literature, and the results of a qualitative analysis as these revealed from the interview of some executive members of Greek companies with experience in high technology companies. Findings indicated that HPWS effect is a complex issue and the use of Informative Technology could affect positively the organization.