Quantitative assessment of cerebral atrophy during and after treatment in children with acute lymphoblastic leukemia

dc.contributor.author	Πρασόπουλος, Παναγιώτης Π.	el
dc.contributor.author	Κάβουρας, Διονύσης Α.	el
dc.contributor.author	Γκολφινόπουλος, Σπυρίδων	el
dc.contributor.author	Ευλογιάς, Νικόλαος	el
dc.contributor.author	Θεοδωρόπουλος, Βασίλης	el
dc.date.accessioned	2015-05-08T08:44:54Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/9924
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://journals.lww.com/investigativeradiology/Abstract/1996/12000/Quantitative_Assessment_of_Cerebral_Atrophy_During.3.aspx	en
dc.subject	Acute lymphoblastic leukemia
dc.subject	Radiotherapy
dc.subject	Οξεία λεμφοβλαστική λευχαιμία
dc.subject	Χημειοθεραπεία
dc.title	Quantitative assessment of cerebral atrophy during and after treatment in children with acute lymphoblastic leukemia	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Internal medicine
heal.classification	Ιατρική
heal.classification	Εσωτερική παθολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85067347
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Εσωτερική παθολογία
heal.keywordURI	http://zbw.eu/stw/descriptor/19529-3
heal.contributorName	Παναγιώτου, Ιωάννης	el
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	1996
heal.bibliographicCitation	Prassopoulos, P., Cavouras, D., Golfinopoulos, S., Evlogias, E., Theodoropoulos, V., et al. (December 1996). Quantitative assessment of cerebral atrophy during and after treatment in children with acute lymphoblastic leukemia. Investigative Radiology. 31(12). pp. 749-754. Lippincott-Raven: 1996.	en
heal.abstract	RATIONALE AND OBJECTIVES: The authors evaluate quantitatively brain atrophy induced by central nervous system prophylaxis in children treated for acute lymphoblastic leukemia during and after therapy completion. METHODS: Measurements of the width of the subarachnoid compartments were performed in 243 brain computed tomography (CT) examinations of 196 children examined during (125) and/or after (71) treatment for acute lymphoblastic leukemia without central nervous system involvement. Data were compared with normative data. RESULTS: Diffuse brain atrophy was observed in 74% and 65% of the CT examinations performed during and after cessation of treatment, respectively. The highest incidence of brain atrophy (78%) occurred during the administration of intrathecal chemotherapy. All children younger than 2 years of age exhibited brain atrophy. CONCLUSIONS: Brain atrophy is the principal CT finding in the majority of children treated for acute lymphoblastic leukemia and it can be attributed mainly to intrathecal chemotherapy. This finding can be observed long after therapy completion.	en
heal.publisher	Lippincott-Raven	en
heal.journalName	Investigative Radiology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true